Email: dhryu@skku.edu
Homepage: http://chem.skku.ac.kr/~dhryu/
Tel: +82-31-290-5931 / Fax: +82-31-290-7075

• 1987.3. – 1991.2. B.S., Department of Chemistry, KAIST
• 1991.3. – 1993.2. M.S., Department of Chemistry, KAIST
• 1993.3. – 1997.2. Ph. D., Department of Chemistry, KAIST
  • Thesis: Stereocontrolled Synthetic Routes to Various syn-beta Amino Alcohol Derivatives (Adviser: Prof. Sung Ho Kang).
• 1997. 1. – 2001. 2. Associate Research Scientist, SK Chemicals, Life Science Institute.
• 2000. 3. – 2002. 1. Postdoc Fellow, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School (with Prof. Robert R. Rando)
• 2002. 1. – 2005.1. Postdoc Fellow, Department of Chemistry and Chemical Biology, Harvard University (with Prof. E. J. Corey)
• 2005. 3. – present Assistant Professor, Department of Chemistry, Sungkyunkwan University
  
  

My major research interests are the development of asymmetric organic catalyst and its application to asymmetric reaction, total synthesis of biologically important molecules and chemical biology based on natural product.

1. Development of Asymmetric Organic Catalyst
   
   1. Chiral proton organocatalyst
      
   2. DMAP based organocatalyst
      
2. New Catalytic Asymmetric Reaction
   1. Catalytic Asymmetric Allylic Amination
3. Chemical Biology Based on Natural Product
   1. Total synthesis as a tool for exploring biology
   2. RNA Targeting Small Molecules

1. Ryu, D. H.; Corey, E. J. “Highly Enantioselective Cyanosilylation of Aldehydes Catalyzed by a Chiral Oxazaborolidinium Ion.” J. Am. Chem. Soc. 2004, 126, 8106-8107.
2. Ryu, D. H.; Zhou, G.; Corey, E. J. “Enantioselective and Structure-Selective Diels-Alder Reactions of Unsymmetrical Quinones Catalyzed by a Chiral Oxazaborolidinium Cation. Predictive Selection Rules.” J. Am. Chem. Soc. 2004, 126, 4800-4802.
3. Kang, S. H.; Kim, M.; Ryu, D. H. “A Stereoselective Synthesis of a Key Intermediate to 1b-methylcarbapenem via Aziridine Ring-opening Reaction.” Synlett 2003, 8, 1149-1150.
4. Ryu, D. H.; Corey, E. J. “Triflimide Activation of a Chiral Oxazaborolidine Leads to a More General Catalytic System for Enantioselective Diels-Alder Addition.” J. Am. Chem. Soc. 2003, 125, 6388-6390.
5. Ryu, D. H.; Tan, C.-H.; Rando, R. R. “Synthesis of (+),(-)-Neamine and their Positional Isomers as Potential Antibiotics.” Bioorg. Med. Chem. Lett. 2003, 13, 901-903.
6. Ryu, D. H.; Lee, T. W.; Corey, E. J. “Broad-Spectrum Enantioselective Diels-Alder Catalysis by Chiral, Cationic Oxazaborolidines.” J. Am. Chem. Soc. 2002, 124, 9992-9993.
7. Ryu, D. H.; Litovchick, A.; Rando, R. R. “Stereospecificity of Aminoglycoside-Ribosomal Interactions.” Biochemistry 2002, 41, 10499-10509.
8. Ryu, D. H.; Rando, R. R. “Decoding Region Bubble Size and Aminoglycoside Antibiotic Binding.” Bioorg. Med. Chem. Lett. 2002, 12, 2241-2244.
9. Ryu, D. H.; Rando, R. R. “Aminoglycoside Binding to Human and Bacterial A-Site rRNA Decoding Region Constructs.” Bioorg. Med. Chem. 2001, 9, 2601-2608.